Evidence-based writing on longevity, healthspan, and the science of ageing well.
Rapamycin has the strongest animal lifespan data of almost any pharmacological intervention. Whether that translates to humans is an open question — and one that ongoing trials may finally answer.
GLP-1 medications are neither cosmetic shortcuts nor miracle cures. Used as part of a broader clinical strategy, they can meaningfully reduce the burden of cardiometabolic disease.
Biological age testing is scientifically interesting, but as marketed today the number is far less precise — and far less actionable — than the way it is sold.
Blood pressure is one of the single most important determinants of brain health. Midlife control protects the small vessels that support cognition long before any symptoms appear.
Standard cholesterol tests show how much cholesterol is on board, but ApoB tells you how many atherogenic particles are in circulation — a more direct measure of the mechanism that drives cardiovascular disease.
The supplement industry is built largely on plausibility, not human trial data. A small number have genuine evidence — vitamin D, omega-3, creatine, magnesium — but they sit well below the foundations that actually move the needle.
Easy exercise is not wasted exercise. Zone 2 training improves how the body uses oxygen and fuel, supports mitochondrial function, and builds the aerobic base that underpins long-term health.
A full eight hours is not always a good eight hours. Disrupted sleep architecture carries its own distinct health costs, and protecting it deserves the same seriousness as diet and exercise.
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