Articles

Preventing Dementia Series

The Metabolic Brain

Blood sugar runs on a continuum, and so do its consequences for the brain. The drifting line in a decade of "normal" blood tests is where prevention begins.

Preventing Dementia Series

The Vascular Brain

The most important thing you can do for your brain in midlife has nothing to do with your brain. It has to do with your arteries. Here is the evidence.

Preventing Dementia Series

How the Brain Ages — and How Much of "Normal" Decline Actually Isn't

Some cognitive change with age is real and biological. But the trajectory most people accept as normal is also the sum of decades of preventable vascular damage, untreated sensory loss, and a slow decline in the demands we place on our brains.

Preventing Dementia Series

The Case for Prevention in Dementia

Dementia is now Australia's leading cause of death. The drugs are modest. But close to half of all cases are theoretically preventable — and the evidence behind that claim should change how we approach the second half of life.

Rapamycin and Longevity — History, Evidence and the Human Trial Question

Rapamycin has the strongest animal lifespan data of almost any pharmacological intervention. Whether that translates to humans is an open question — and one that ongoing trials may finally answer.

GLP-1 Medications and Healthspan — Beyond Weight Loss

GLP-1 medications are neither cosmetic shortcuts nor miracle cures. Used as part of a broader clinical strategy, they can meaningfully reduce the burden of cardiometabolic disease.

Biological Age Testing — Useful Signal or Marketing Noise?

Biological age testing is scientifically interesting, but as marketed today the number is far less precise — and far less actionable — than the way it is sold.

Blood Pressure and Brain Ageing — Why Midlife Control Matters

Blood pressure is one of the single most important determinants of brain health. Midlife control protects the small vessels that support cognition long before any symptoms appear.

ApoB, LDL and Cardiovascular Risk — Looking Beyond the Standard Cholesterol Test

Standard cholesterol tests show how much cholesterol is on board, but ApoB tells you how many atherogenic particles are in circulation — a more direct measure of the mechanism that drives cardiovascular disease.

Supplements — What the Evidence Actually Shows

The supplement industry is built largely on plausibility, not human trial data. A small number have genuine evidence — vitamin D, omega-3, creatine, magnesium — but they sit well below the foundations that actually move the needle.

Zone 2 Training and Metabolic Health — Why Easy Exercise Is Not Wasted Exercise

Easy exercise is not wasted exercise. Zone 2 training improves how the body uses oxygen and fuel, supports mitochondrial function, and builds the aerobic base that underpins long-term health.

Sleep Architecture and Healthspan — Why Quality Matters as Much as Quantity

A full eight hours is not always a good eight hours. Disrupted sleep architecture carries its own distinct health costs, and protecting it deserves the same seriousness as diet and exercise.