Dr Hugh Leslie is an Australian physician with a special interest in longevity and healthspan optimisation. His approach is grounded in the best available evidence — separating signal from noise in a field that attracts both genuine science and considerable hype.
Rapamycin has the strongest animal lifespan data of almost any pharmacological intervention. Whether that translates to humans is an open question — and one that ongoing trials may finally answer.
GLP-1 medications are neither cosmetic shortcuts nor miracle cures. Used as part of a broader clinical strategy, they can meaningfully reduce the burden of cardiometabolic disease.
Biological age testing is scientifically interesting, but as marketed today the number is far less precise — and far less actionable — than the way it is sold.
Most medicine waits for something to go wrong. My interest is in the years before that — the decisions, habits and investigations that determine whether someone reaches their seventies and eighties with full function, or merely alive. I trained as a GP before developing a specialist focus in healthspan optimisation, drawn by a simple observation: the gap between what the evidence shows is possible and what most people are told — is enormous.
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